Abcam, ab122701, Anti-Asef2 antibody

Size: 100µL
Rabbit Polyclonal Asef2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Spermatogenesis-associated protein 13 aa 550-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Spermatogenesis-associated protein 13 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.Q96N96

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Asef2 also known as SPATA13 is a Rac-specific guanine nucleotide exchange factor (GEF) that primarily influences actin cytoskeleton dynamics. It has a mass of approximately 91 kDa and contains a DH-PH domain arrangement. Asef2 is expressed in various tissues including the brain kidney and testis. Its role involves modulating the activity of small GTPases particularly Rac1 which are critical for cellular morphological adjustments.
Biological function summary
In the context of cellular dynamics Asef2 facilitates the reorganization of the cytoskeleton by promoting actin filament assembly and stability. It acts within the context of protein complexes that regulate cell migration and adhesion. Asef2's function influences cellular processes like neurite outgrowth and cell junction assembly thereby supporting cell motility and intercellular communication.
Pathways
The function of Asef2 integrates into signaling cascades that control cytoskeletal architecture and cell movement. Asef2 prominently interacts with pathways involving the Wnt signaling pathway where it works with proteins such as APC and β-catenin to influence cell division and migration processes. Additionally it plays a role in the integrin signaling pathway coordinating with proteins like paxillin to affect adhesion and motility.
Asef2 displays relevance in cancer metastasis and neurodegenerative disorders. Its aberrant expression associates with the progression of certain cancer types including colorectal cancer where it may enable cancerous cells to invade and metastasize. In neurodegenerative disorders like Alzheimer's disease Asef2's interaction with tau protein suggests its involvement in neuronal dysfunction and degradation. Through these interactions Asef2 may contribute to both the development and progression of these pathological conditions.