Abcam, ab122769, Anti-SKAP antibody

Size: 100µL
Rabbit Polyclonal SKAP antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KNSTRN aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KNSTRN aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y448

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SKAP also known as Src Kinase-Associated Phosphoprotein of 55 kDa is an adaptor protein that plays an important role in T cell activation. It weighs approximately 55 kDa and is prominently expressed in lymphoid tissues where it supports the immune response. Functionally SKAP forms part of signaling cascades that transmit extracellular signals into the cell interior modulating cellular activities.
Biological function summary
SKAP regulates immune cell function by influencing adhesion and migration processes. It often forms part of larger complexes within the immune synapse facilitating interactions between proteins necessary for efficient signaling. SKAP's role in T cells involves partnering with other signaling molecules to strengthen immune responses against infections by promoting cell adhesion.
Pathways
SKAP participates actively in the T-cell receptor (TCR) signaling and integrin-mediated pathways. It associates with proteins such as LFA-1 an important integrin that mediates cell adhesion. SKAP affects the downstream signaling events by modulating key interactions and conformations which are important for effective immune response initiation and regulation.
SKAP has notable connections with autoimmune diseases like rheumatoid arthritis and multiple sclerosis. Its deregulation affects the immune system's balance leading to exacerbated inflammatory responses. Connections to proteins like RapL which interacts with integrins to regulate cell adhesion and migration imply its involvements in pathological conditions involving the immune system's improper regulation.