Abcam, ab122786, Anti-TMEM111 antibody

Size: 100µL
Rabbit Polyclonal TMEM111 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EMC3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EMC3. The exact immunogen used to generate this antibody is proprietary information.Q9P0I2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM111 also known as transmembrane protein 111 is integral to the endoplasmic reticulum membrane. Weighing approximately 26 kDa this protein facilitates various cellular processes. TMEM111 is expressed widely across different tissues including the brain liver and kidney. Its expression pattern indicates significant involvement in maintaining several cell functions and indicates its potential role in cellular homeostasis.
Biological function summary
TMEM111 plays a part in regulating the Bat3 complex contributing to protein quality control within the cell. This protein interacts with other components to ensure correct protein folding and degradation of misfolded proteins. Its activity is essential for maintaining cellular stress responses and cellular viability. Through these interactions TMEM111 supports cell survival mechanisms and prevents the accumulation of defective proteins that could harm cellular operations.
Pathways
TMEM111 contributes to the ubiquitin-proteasome pathway and is linked with the endoplasmic reticulum-associated degradation (ERAD) pathway. It interacts closely with proteins such as ubiquitin-conjugating enzymes and other ERAD components playing a significant role in the targeted degradation of misfolded proteins. These pathways are critical for maintaining protein homeostasis preventing cellular damage from protein aggregation especially under conditions that induce endoplasmic reticulum stress.
TMEM111 shows an association with neurodegenerative diseases like Alzheimer's disease and liver disorders. Dysfunctional TMEM111 may contribute to the accumulation of misfolded proteins seen in Alzheimer's likely by disrupting the ERAD pathway. In liver disorders its interaction with proteins like hepatic-specific factors suggests a role in liver function maintenance. Further investigation into TMEM111 could offer insights into therapeutic targets for these conditions.