Abcam, ab122809, Anti-SAC3D1 antibody

Size: 100µL
Rabbit Polyclonal SAC3D1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SAC3D1 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SAC3D1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.A6NKF1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAC3D1 also known as SH3- and SAC domain-containing protein 1 is a protein that plays a mechanical role in intracellular transport and phosphoinositide metabolism. The protein has a mass of approximately 94 kDa and is expressed in various tissues with higher levels in the brain and testis. SAC3D1 contains an SH3 domain and a phosphatase domain which are important for its function in cellular processes.
Biological function summary
SAC3D1 interacts with other proteins to form a complex critical for phosphatidylinositol-3-phosphate binding and turnover. This activity is essential in membrane trafficking regulating endosomal dynamics and impacting cellular signaling pathways. SAC3D1's ability to mediate phosphoinositide signaling suggests that it plays a role in cell growth and differentiation maintaining normal cellular functions.
Pathways
SAC3D1 is involved in the phosphoinositide signaling pathway and the endocytic recycling pathway. These pathways include interactions with proteins like MTMR2 and FIG4 which are important for lipid phosphatase activity and vesicle recycling. SAC3D1's association with these proteins highlights its influence on maintaining endosome homeostasis within cells important for proper signaling and trafficking functions.
SAC3D1 has been linked to conditions such as Charcot-Marie-Tooth disease and Amyotrophic Lateral Sclerosis (ALS). Its interactions with the FIG4 protein is significant as mutations in FIG4 relate to these disorders. Disruptions in SAC3D1 function can lead to defects in lipid metabolism and neuronal maintenance contributing to the pathogenesis of these neurodegenerative diseases.