Abcam, ab12369, Anti-Syntaxin 2/STX2 antibody

Size: 50µg
Rabbit Polyclonal Syntaxin 2/STX2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Rat Stx2 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Stx2 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P50279

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was purified on a peptide bound immunoaffinity column., Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Syntaxin 2 (STX2) also known as epimorphin plays an important role in the process of vesicle fusion in cells. This protein is part of the t-SNARE family and has a molecular mass of approximately 33 kDa. STX2 is expressed in various tissues including the brain lungs and kidneys indicating its widespread involvement in cellular processes throughout the body.
Biological function summary
Syntaxin 2 mediates intracellular membrane fusion events. It functions as a component of the SNARE complex which facilitates vesicle targeting and fusion with cell membranes. This activity is necessary for secretory pathways and endocytic processes ensuring proper transport and release of cellular materials. In addition STX2 takes part in regulating insulin exocytosis highlighting its role in maintaining metabolic balance.
Pathways
The protein is central to the vesicular transport and secretory pathways. It interacts with other SNARE proteins like SNAP-25 and VAMP2 forming a complex that drives membrane fusion. Syntaxin 2 also has a connection with the insulin signaling pathway highlighting its contribution to glucose homeostasis and energy metabolism. These interactions show its participation in critical cellular communication and transport pathways.
Syntaxin 2 is linked to certain metabolic and neurological conditions. Its involvement in insulin secretion suggests a connection to type 2 diabetes where dysregulation can affect insulin release. Additionally altered expression or function of STX2 has been examined in neurodegenerative diseases such as Alzheimer's disease. Disruptions involving proteins like APP in conjunction with STX2 might contribute to the development of such disorders indicating STX2's potential as a therapeutic target.