Abcam, ab123880, Anti-IRF6 antibody [OTI2A12]

Size: 100µL
Mouse Monoclonal IRF6 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, African green monkey, Transfected cell line samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IRF6.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2A12,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human, African green monkey,
Applications:IHC-P, ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IRF6.O14896

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon Regulatory Factor 6 (IRF6) is a transcription factor known for its role in the regulation of gene expression involved in developmental processes. It weighs approximately 53 kDa and it is part of the IRF family of transcription factors. This protein is predominantly found in the epithelial tissues where it plays a critical role in keratinocyte differentiation and proliferation. The expression of IRF6 can be observed in several tissues but it is especially important in the oral epithelium skin and hair follicles.
Biological function summary
IRF6 orchestrates various cellular activities essential for tissue development and repair. It functions as a transcriptional activator influencing the expression of genes involved in the morphogenesis of craniofacial structures. IRF6 does not form large protein complexes but rather exerts its function through interaction with DNA and possibly with other transcription factors. It contributes to epithelial differentiation and proliferation balancing growth and apoptosis in tissues.
Pathways
IRF6 participates significantly in the Wnt and Notch signaling pathways. Both pathways are critical for regulating cell fate and development processes. The Notch pathway influences differentiation in the epithelial cells while the Wnt pathway is key for controlling the balance between growth and differentiation. IRF6 interacts with proteins such as RIPK4 which mediates signaling important for preventing excessive proliferation by promoting differentiation processes.
IRF6 mutations link to conditions such as Van der Woude syndrome and orofacial clefting which involve developmental anomalies in facial structures. These mutations may disrupt normal protein function impacting critical pathways and their downstream effects. IRF6 dysfunction in these disorders may also involve interactions with other proteins like p63 influencing epithelial development negatively and contributing to the clinical manifestations observed in these conditions.