Abcam, ab123929, Anti-XPNPEP1 antibody [OTI1E3]

Size: 100µL
Mouse Monoclonal XPNPEP1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Dog, Rat, African green monkey, Transfected cell lysate - Human, Recombinant fragment - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human XPNPEP1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1E3,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Dog, Human, African green monkey,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human XPNPEP1.Q9NQW7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab123929 is purified from Mouse ascites fluid by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The XPNPEP1 protein also known as X-prolyl aminopeptidase 1 or aminopeptidase P functions as a cytosolic enzyme and possesses a zinc-binding motif. It cleaves N-terminal amino acids from peptides containing proline. This enzyme has a mass of approximately 65 kDa. XPNPEP1 is expressed in various tissues with high expression levels observed in the kidney and liver. It operates as a monomeric enzyme and requires metal ions for its catalytic activity.
Biological function summary
XPNPEP1 plays a role in protein and peptide metabolism by processing proline-containing substrates. It does not associate with any catalytic complexes but functions autonomously to modulate peptide availability and activity. Its enzymatic activity aids in regulating peptides involved in cellular signaling and function. XPNPEP1 helps maintain homeostasis by ensuring the correct processing and degradation of proline-containing peptides which can influence numerous physiological processes.
Pathways
XPNPEP1 participates in the renin-angiotensin system (RAS) and the bradykinin degradation pathway. In the RAS XPNPEP1 modulates angiotensin molecules therefore impacting blood pressure regulation. It interacts with angiotensin-converting enzyme (ACE) within this system. In the bradykinin degradation pathway XPNPEP1 helps break down bradykinin peptides therefore preventing prolonged inflammatory responses and vascular permeability changes. Its activity is important in maintaining balance within these systems.
XPNPEP1 has links to hypertension and renal diseases due to its involvement in blood pressure and fluid balance regulation. Its association with ACE makes it relevant to conditions like hypertension where ACE inhibitors are often treatment choices. Additionally changes in XPNPEP1 expression or activity can contribute to renal dysfunction given its significant expression in kidney tissues. Research on XPNPEP1 could lead to better understanding and treatment of these cardiovascular and renal conditions.