Abcam, ab123936, Anti-TRPM4 antibody [OTI10H5]

Size: 100µL
Mouse Monoclonal TRPM4 antibody. Suitable for IHC-P, WB and reacts with Human, Dog, African green monkey, Transfected cell lysate - Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRPM4.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI10H5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Dog, Human, African green monkey,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TRPM4.Q8TD43

Product details:
Clone OTI10H5 (formerly 10H5).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRPM4 also known as Transient Receptor Potential Melastatin 4 is a calcium-activated non-selective cation channel with a mass of approximately 138 kilodaltons. This protein allows the movement of monovalent cations such as sodium across the plasma membrane leading to membrane depolarization. TRPM4 expresses in numerous human tissues including the heart brain and immune cells. Researchers often study this channel to understand its role in cellular electric activities.
Biological function summary
TRPM4 plays an important part in regulating membrane potential and cellular excitability. It does not function as part of a larger structural complex but its activity modulates various cellular processes. For instance it is important in cardiac conduction influencing heart rhythm by affecting the action potential duration. In immune cells TRPM4 contributes to cytokine release and cell movement impacting the body’s inflammatory response.
Pathways
TRPM4's mechanism integrates into significant signaling pathways like the calcium signaling pathway and the cardiac conduction system. Within these pathways its function influences several key proteins. In the calcium signaling pathway TRPM4's activity can affect the function of calmodulin an important calcium sensor while in cardiac cells TRPM4 regulates voltage-gated calcium channels important for heart muscle contraction.
TRPM4’s roles associate it with conditions like cardiac arrhythmias and multiple sclerosis. In heart diseases TRPM4 interacts with proteins such as Na+/Ca2+ exchangers and abnormalities in this interaction can lead to arrhythmogenic conditions. For multiple sclerosis studies suggest that altered TRPM4 activity in immune cells impacts the immune response potentially linking it to the disease's progression. Understanding these interactions can provide insights for therapeutic targets.