Abcam, ab124268, Anti-Treslin antibody

Size: 100µg
Rabbit Polyclonal Treslin antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TICRR aa 950-1050.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TICRR aa 950-1050. The exact immunogen used to generate this antibody is proprietary information.Q7Z2Z1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab124268 was affinity purified using an epitope specific to Treslin immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Treslin also known as TICRR is a protein that plays an important role in initiating DNA replication. It has a molecular mass of approximately 220 kDa. Treslin is expressed in various human tissues with significant levels observed in cell types that actively undergo division. Mechanically Treslin primarily functions in the S phase of the cell cycle enabling the transition from the G1 phase to the S phase. It does so by interacting with other replication factors facilitating the assembly of the pre-replicative complex necessary to commence DNA synthesis.
Biological function summary
Treslin holds a significant position in the progression of the cell cycle. It participates in complex formation with other proteins such as TopBP1 where it supports replication initiation by recruiting and stabilizing additional replication machinery components. Treslin is necessary for the loading of Cdc45 onto replication origins. It ensures precise control over DNA replication preventing unscheduled or erroneous replication events which can lead to genomic instability.
Pathways
Treslin operates in pivotal DNA replication and cell cycle control pathways. It works closely with proteins like Cdc45 and TopBP1 within the DNA replication start pathway and the cell cycle's S-phase entry process. Treslin's interactions with these proteins ensure that DNA replication starts accurately within the cell cycle framework thereby maintaining genomic integrity and proper cell function.
Researchers associate Treslin with cancer development and progression. Its malfunction or aberrant expression can result in genomic instability promoting oncogenesis. Treslin's interaction with TopBP1 also ties it to disorders involving cellular cycle dysregulation. Understanding Treslin's role in these disease pathways may help design therapeutic strategies that target replication machinery components to inhibit cancer cell proliferation.