Abcam, ab124290, Anti-MCM-BP antibody

Size: 100µg
Rabbit Polyclonal MCM-BP antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MCMBP aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MCMBP aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q9BTE3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab124290 was affinity purified using an epitope specific to MCM-BP immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein MCM-BP also known as Minichromosome Maintenance Binding Protein functions as a modulator in DNA replication. This protein works by interacting with MCM complexes to regulate their activity. MCM-BP has a molecular mass of approximately 97 kDa and is expressed in several human tissues with high levels observed in proliferating cells such as those in the liver and testes. This indicates its important role in cell replication processes.
Biological function summary
The MCM-BP protein plays a role in overseeing DNA synthesis ensuring that genetic material duplicates correctly during cell division. It forms part of the DNA replication licensing complex interacting with components of the MCM complex to unload them from DNA after replication initiation. By regulating these complexes MCM-BP helps maintain the integrity and fidelity of the replication process. The protein aids in preventing genome instability which is critical for normal cellular function.
Pathways
One can understand the involvement of MCM-BP in the DNA replication pathway and the cell cycle regulation pathway. It interacts closely with proteins in the Minichromosome Maintenance (MCM) complex specifically with the helicase activity important for DNA unwinding during replication. By controlling MCM complex disassembly MCM-BP ensures the proper progression and completion of the replication process linking it to an orderly passage through the cell cycle phases.
MCM-BP has associations with certain cancers and genomic instability disorders. Its dysregulation can lead to improper DNA replication resulting in mutations and an increased risk of tumor development. For example in some cancers abnormal MCM-BP activity is observed contributing to the unchecked proliferation of cancer cells. Additionally its connection with proteins like p53 highlights its relevance in pathways that when faltered contribute to oncogenesis and other replication-related disorders.