Abcam, ab124678, Anti-DP1 antibody [EPR4959(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DP1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4959(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DP1 receptor also known as the prostaglandin D2 receptor 1 is a G-protein-coupled receptor with a molecular mass of approximately 44 kDa. This receptor binds to prostaglandin D2 (PGD2) and is found in various tissues including the central nervous system lungs and some immune cells. The presence of DP1 in these tissues suggests a role in multiple physiological processes reflecting its distribution in the body.
Biological function summary
Prostaglandin D2 (PGD2) plays a significant role in mediating inflammatory and allergic responses. The DP1 receptor is part of a signaling complex that modulates smooth muscle relaxation inhibition of platelet aggregation and sleep induction. Its expression in both neural and peripheral tissues underlines its involvement in a range of biological functions including the regulation of sleep-wake cycles and inflammation.
Pathways
The DP1 receptor contributes significantly to the prostaglandin signaling pathway which involves other prostaglandin receptors such as DP2 and EP receptors. This pathway mediates various physiological responses including vasodilation and immune modulation. The signaling interactions between DP1 and these related receptors help coordinate complex biological processes such as the regulation of vascular tone and inflammatory responses.
Abnormal DP1 signaling relates to asthma and allergic rhinitis conditions where inflammation and immune response are dysregulated. Overactivation or altered regulation of DP1 can exacerbate these diseases often involving other proteins like COX-2 which elevate levels of PGD2 during inflammation. Understanding DP1's role offers potential therapeutic angles for managing allergic and inflammatory diseases.