Abcam, ab124803, Anti-Cadherin 9 antibody [EPR5113]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Cadherin 9 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5113,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cadherin-9 also known as CDH9 is a classical cadherin protein with a critical role in cell adhesion. This protein has a molecular mass of approximately 130 kDa. Cadherin-9 is part of the cadherin superfamily characterized by calcium-dependent cell-cell adhesion. It is expressed in neural tissues particularly within the brain where it facilitates neuron-neuron adhesion by forming adherens junctions. This adhesive function is essential for maintaining proper cellular architecture in tissues.
Biological function summary
Cadherin-9 contributes to the establishment and maintenance of cell-cell junctions. It is not part of a complex but associates strongly with other cadherin proteins maintaining tissue structure and signaling within cadherin-mediated junctions. The protein's adhesive properties are critical to neural development where it influences axonal guidance synapse formation and the stabilization of neuronal circuits. This role ensures accurate neural connectivity essential for proper brain functioning.
Pathways
The role of Cadherin-9 connects to key signaling pathways involving Wnt and calcium-dependent pathways. Within these pathways Cadherin-9 interacts with proteins like beta-catenin which links to the intracellular domain of cadherins at cell junctions and is involved in signal transduction. The interaction of Cadherin-9 within these pathways implicates it in the regulation of cellular activities like differentiation proliferation and cell polarity which are necessary for proper tissue development and homeostasis.
Cadherin-9 shows association with neurodevelopmental disorders such as autism and intellectual disabilities. In these conditions abnormal Cadherin-9 expression or function affects neuronal connectivity and synaptic stability. The protein also relates to the protein neuroligin which plays a role in synapse formation and is implicated in autism spectrum disorders. The Cadherin-9 and neuroligin interaction suggests pathways where disrupted cell adhesion and signaling impact neural circuitry formation and cognitive development.