Abcam, ab124875, Anti-SARA antibody [EPR5020]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SARA antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5020,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARA also known as Smad anchor for receptor activation plays an important mechanical role in cellular signaling. It functions by binding to phosphorylated receptor-regulated Smad proteins (R-Smads) and facilitating their movement and accumulation in the nucleus. SARA has a molecular mass of approximately 150 kDa and is prominently expressed in a variety of tissues including the brain liver and kidney indicating a widespread functional role in physiological processes.
Biological function summary
SARA engages in interactions with several signaling molecules in the cell. It acts as a scaffolding protein that forms part of a complex with the Smad proteins assisting in the regulation of transforming growth factor-beta (TGF-β) signaling. By serving as a critical link between membranes and the cytoplasm it ensures the accurate transmission of signals necessary for cellular responses. Its location and function highlight its vital role in maintaining cellular homeostasis.
Pathways
SARA plays an important role in TGF-β and bone morphogenetic protein (BMP) signaling pathways. These pathways are essential for regulating cellular processes such as proliferation differentiation and apoptosis. SARA interacts with Smad2 Smad3 and Smad7 which are key components of these pathways. Through these interactions SARA helps mediate the transduction of signals that guide complex cellular activities and responses linking external signals to gene expression inside the nucleus.
Research has linked SARA to cancer and fibrotic diseases. Its role in TGF-β signaling suggests that alterations in SARA expression or function can contribute to tumor progression and metastatic processes. Additionally in fibrotic diseases where excess tissue scarring occurs the modulation of the pathway by proteins like Smad2 and Smad3 with SARA's involvement can result in aberrant tissue responses. Understanding SARA's involvement in these conditions may offer potential therapeutic insights.