Abcam, ab124889, Anti-Mitochondrial Ferritin antibody [EPR1797]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Mitochondrial Ferritin antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1797,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mitochondrial ferritin also known as ferritin 23 and abbreviated as FtMt is a protein that is part of the ferritin family. This mitochondrial protein displays a distinct structure with a molecular mass of approximately 150 kDa. It predominantly localizes in the mitochondria of cells where it serves an important role in iron storage. Unlike cytosolic ferritin which consists of H and L subunits mitochondrial ferritin arises as a homopolymer composed of 24 identical subunits. It is considered essential for maintaining mitochondrial iron homeostasis.
Biological function summary
Mitochondrial ferritin contributes to iron storage within mitochondria safeguarding cells from iron-mediated oxidative stress. It operates independently and does not incorporate into larger complexes like cytosolic ferritin does. Mitochondrial ferritin sequesters iron in a mineral form reducing the production of reactive oxygen species (ROS) that can damage cellular components. Its expression is particularly high in iron-rich tissues such as the testis and neurons suggesting a significance in tissues with active iron metabolism.
Pathways
Mitochondrial ferritin participates in iron metabolism and oxidative stress response. It affects the interaction with proteins like cytosolic ferritin and the transferrin receptor which are components of iron homeostasis pathways. Mitochondrial ferritin serves as a protective element by regulating iron storage within the mitochondria linking it to pathways that modulate oxidative stress. This interplay maintains cellular iron levels and prevents toxicity.
Mitochondrial ferritin's imbalance associates with neurodegenerative diseases and anemia. Neurodegenerative conditions such as Friedreich's ataxia reveal alterations in iron homeostasis where mitochondrial ferritin's role becomes apparent due to its protective function against mitochondrial damage. In anemia abnormal iron management results in either iron overload or deficiency where ferritin and transferrin receptor also play important roles. Understanding mitochondrial ferritin's function helps elucidate its contributions to the pathology of these conditions.