Abcam, ab124996, Anti-THOC5 antibody [EPR6905(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal THOC5 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6905(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THOC5 also known as Fms-interacting protein 1 (FIP1L1) or HPR1 is a component of the transcription/export (TREX) complex. With a mass of around 100 kDa THOC5 operates at the intersection of transcription and mRNA processing. This protein localizes mainly in the nucleus where it executes its role in RNA metabolism. THOC5 is necessary for transporting newly synthesized mRNA from the nucleus to the cytoplasm and is constitutively expressed in various tissues including liver and testis.
Biological function summary
This THOC5 protein plays an important role in mRNA processing and export. As part of the TREX complex it assists in coupling transcription with mRNA processing and subsequent export. Through its orchestrated activity THOC5 facilitates the efficient flow of genetic information from DNA to protein synthesis machinery. THOC5 influences the stability and quality of mRNA transcripts by directly binding to certain RNA sequences.
Pathways
One can find THOC5 participating in the mRNA splicing and transport pathways. This protein's role is integrally linked with the DNA-directed RNA polymerase II contributing to the processes that manage RNA synthesis and modification. Additionally THOC5 interacts with other components of the TREX complex such as THOC2 and THOC7 to maintain proper RNA metabolism and cellular function.
THOC5 has relevance to cancer. Some studies have found dysregulation of THOC5 in various malignancies including leukemia and liver cancer. Its association with the FUS protein suggests a link to neurodegenerative conditions since FUS mutations show involvement in amyotrophic lateral sclerosis (ALS). Imbalances in THOC5 levels can cause aberrant mRNA processing contributing to disease progression.