Abcam, ab125574, Recombinant human YANK2 protein

Size: 5µg / 10µg
Recombinant human YANK2 protein is a Human Full Length protein, in the 1 to 414 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB, FuncS.
Key facts
Purity:>95% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:FuncS, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab125574 was determined to be 14 nmol/min/mg.,
Accession:Q9NY57,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Product details:
ab64311
(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YANK2 also known as YANK1B is a regulatory protein with a mass of approximately 35 kDa. It functions within cells by binding to phospholipids which influences various membrane-related processes. YANK2 expresses strongly in the brain and heart with moderate expression in the lungs liver and kidney. It typically localizes to the cytoplasmic side of the plasma membrane playing a significant role in signal transduction and membrane dynamics.
Biological function summary
The YANK2 protein involves itself in cellular processes through its interaction with other signaling proteins. It forms part of the membrane-associated complex important for transducing signals from external stimuli into intracellular responses. YANK2 contributes to cellular communication by modulating phosphoinositide levels which are key secondary messengers in signaling pathways. This involvement affects various cellular functions including growth movement and differentiation.
Pathways
YANK2 integrates itself into significant signal transduction pathways such as the PI3K/AKT and MAPK/ERK pathways. Within these pathways YANK2 interacts with proteins like PIP2 and AKT influencing cell survival and metabolism. YANK2's regulatory role ensures proper signal relay and cellular adaptation to environmental cues supporting cellular homeostasis and response to stress.
YANK2 has strong ties to conditions such as cancer and cardiovascular diseases. Abnormal expression or mutations in YANK2 disrupts normal signaling pathways such as those involving PI3K/AKT which can lead to unchecked cell proliferation or impaired cardiac functions. YANK2's association with PIP2 and AKT indicates its important role in maintaining cellular integrity and preventing pathological states.