Abcam, ab125647, Recombinant human PDE4C protein

Size: 5µg / 10µg
Recombinant human PDE4C protein is a Human Fragment protein, in the 287 to 712 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>80% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab125647 was determined to be 83 nmol/min/mg.,
Accession:Q08493,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.005% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDE4C also known as phosphodiesterase 4C is an enzyme that breaks down cyclic adenosine monophosphate (cAMP) to regulate its cellular levels. This target has a mass of approximately 80 kDa. PDE4C is expressed in various tissues including the brain lung and immune cells. It belongs to the larger group of PDE4 enzymes which share similar functions in hydrolyzing cAMP and are key in controlling cellular responses to extracellular signals.
Biological function summary
PDE4C modulates intracellular cAMP levels to influence various physiological functions. It does not function alone; rather it is a part of a regulatory complex that includes other PDE4 isoforms. This regulation of cAMP is important in processes like immune response mood regulation and cognitive function. The enzyme's role implies its involvement in controlling inflammation by modulating immune cell movement and activation.
Pathways
PDE4C plays significant roles in both the cAMP signaling pathway and the inflammatory response pathway. The cAMP pathway involves several proteins including adenylyl cyclase which synthesizes cAMP and protein kinase A (PKA) which is activated by cAMP. Through these interactions PDE4C influences signal transduction and regulatory mechanisms in cellular responses including those linked to inflammation and neural processes.
PDE4C associates with conditions such as asthma and depression. Its dysregulation can lead to abnormal inflammatory responses or altered neurotransmission. In asthma PDE4C affects airway reactivity and inflammation through interactions with other PDE4 enzymes such as PDE4A. In depression altered cAMP signaling involving PDE4C influences mood regulation and neuroplasticity highlighting its potential impact on psychological states and responses.