Abcam, ab125663, Recombinant human p38 beta/MAPK11 protein

Size: 5µg / 10µg
Recombinant human p38 beta/MAPK11 protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB, FuncS.
Key facts
Purity:>95% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:FuncS, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab125663 was determined to be 780 nmol/min/mg.,
Accession:Q15759,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target p38 beta also known as MAPK11 is a member of the mitogen-activated protein kinase (MAPK) family specifically the p38 MAPK subfamily. It weighs approximately 41 kDa and can be expressed in various tissues but shows higher levels in skeletal muscle and heart tissue. This protein operates as a serine/threonine kinase playing an important role in delivering signals from the cell surface to the DNA in the cell nucleus. p38 beta influences transcription factors leading to the regulation of gene expression in response to external stimuli.
Biological function summary
The p38 beta/MAPK11 protein serves an essential role in cellular processes such as inflammation cell differentiation and apoptosis. It can form part of a larger signaling complex that is activated by various stress signals including cytokines and environmental stress suggesting its involvement in stress response pathways. The activation of this kinase results in the phosphorylation of downstream targets leading to various biological responses.
Pathways
P38 beta/MAPK11 is important in the MAPK signaling pathway and is closely linked to the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway. In these pathways it interacts with other proteins such as MKK3 and MKK6 which are upstream activators. This pathway mediates responses to stress and inflammatory cytokines and regulates the production of inflammatory proteins and apoptosis-related factors.
P38 beta/MAPK11 plays an important role in conditions like cancer and chronic inflammatory diseases. Its modulation can affect cancer cell proliferation where it interacts with other MAPK family members. Alterations in the p38 MAPK signaling have been associated with rheumatoid arthritis where p38 beta works alongside p38 alpha to mediate pro-inflammatory cytokine production. Understanding these connections helps develop targeted therapies for these diseases.