Abcam, ab125786, Recombinant human PDE7A/HCP1 protein

Size: 10µg
Recombinant human PDE7A/HCP1 protein is a Human Fragment protein, in the 104 to 456 aa range, expressed in Baculovirus infected Sf9 cells, with >85%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>85% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab125786 was determined to be 166 nmol/min/mg.,
Accession:Q13946,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.4% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

Product details:
This product was previously labelled as PDE7A

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDE7A also known as HCP1 is a phosphodiesterase enzyme responsible for breaking down cAMP an important signaling molecule in cells. This protein has a molecular weight of approximately 52 kDa. PDE7A is expressed in various tissues including muscles and immune cells. It plays a role in regulating cellular levels of cAMP which affects various physiological processes. HCP1 and HCP1 protein are common alternate labels used to refer to PDE7A.
Biological function summary
PDE7A influences immune response and muscle functions through its enzymatic activity on cAMP. The protein does not function alone but participates within larger protein complexes that modulate cAMP signaling. Its activity can affect immune cell activation offering an important checkpoint in the immune system. Additionally PDE7A's interaction with muscle cells highlights its role in controlling muscle contraction and energy metabolism.
Pathways
PDE7A has significant roles emphasizing the cAMP and immune signaling pathways. It helps control the levels of cAMP which is important for signal transduction. PDE7A interacts with proteins like PKA (Protein Kinase A) that rely on cAMP as a secondary messenger. Through this pathway PDE7A contributes to regulating processes such as inflammatory responses and metabolic pathways interlinking with other proteins like CREB which influences gene expression.
PDE7A's role connects it to conditions such as inflammatory diseases and certain muscular disorders. Abnormal PDE7A function can lead to dysregulation in inflammation implicating it in diseases such as rheumatoid arthritis. In the context of muscular disorders PDE7A levels affect muscle function and are related to conditions such as muscle dystrophy. It shares connections with TNF-alpha a protein involved in inflammation and immune system regulation further linking PDE7A to these disorders.