Abcam, ab126256, Anti-ABL2 antibody

Size: 50µL
Rabbit Polyclonal ABL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABL2 aa 50-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ABL2 aa 50-450. The exact immunogen used to generate this antibody is proprietary information.P42684

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABL2 also known as ARG (Abelson-related gene) is a non-receptor tyrosine kinase with a mass of approximately 120 kDa. It shares structural similarities with its relative ABL1 and is primarily localized in the cytoplasm and nucleus of cells. Expression of ABL2 occurs in various tissues including the brain where it plays significant roles in neuronal development. ABL2 functions mechanically by transferring a phosphate group from ATP to tyrosine residues on specific substrates which modulates the activity and function of these substrates.
Biological function summary
ABL2 contributes to cellular processes such as actin cytoskeleton remodeling cell migration and adhesion. This protein interacts with different binding partners through its SH2 and SH3 domains implicating it in cellular signal transduction. ABL2 has been observed to occasionally form part of complexes that regulate these processes contributing to dynamic changes in cell morphology and motility.
Pathways
ABL2 plays a significant role in the downstream signaling of receptor tyrosine kinases and integrins linking it to pathways like the PDGF and VEGF signaling pathways. ABL2 interacts with proteins such as CRK and C3G which influence cytoskeletal reorganization and cellular responses to external stimuli. These interactions highlight its role in conveying signals from the cell surface to internal signaling cascades.
ABL2 shows connections to various types of cancer including glioblastoma and chronic myeloid leukemia. Genetic alterations or dysregulation of ABL2 activity can lead to abnormal cellular proliferation and migration contributing to these malignancies. In particular the oncogenic fusion protein BCR-ABL derived from ABL1 is a well-known factor in leukemia and disruptions in ABL2 can similarly impact oncogenic signaling pathways. Research is ongoing to further understand ABL2’s involvement in tumorigenesis and its potential as a therapeutic target.