Abcam, ab126352, Anti-DPY30 antibody

Size: 100µL
Rabbit Polyclonal DPY30 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DPY30.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DPY30. The exact immunogen used to generate this antibody is proprietary information.Q9C005

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DPY30 also known as Dpy-30-like protein or DPy-30 homolog is a component of the MLL/SET1 histone methyltransferase complexes implicated in histone H3 lysine 4 (H3K4) methylation. This protein has an estimated molecular mass of approximately 9 kDa. It is widely expressed in different tissues which indicates its importance across various cellular environments. The primary role of DPY30 involves facilitating the catalytic activity within these complexes influencing the transcriptional states by modulating chromatin structure.
Biological function summary
DPY30 functions as a core component of the SET1A and SET1B complexes participating in the regulation of gene expression by promoting the trimethylation of H3K4. This histone modification is associated with transcriptionally active chromatin influencing gene activation. DPY30 cooperates with other components like RBBP5 and WDR5 to achieve this modification. By modulating gene expression DPY30 is critical in processes like differentiation and development.
Pathways
DPY30 is deeply involved in chromatin modification and gene transcription pathways. It plays a significant role in the Wnt signaling pathway known for its involvement in developmental processes and cell growth. DPY30 interacts with related proteins within these pathways such as ASH2L which functions as another component of the SET1/MLL complexes to exert its effects on chromatin dynamics and transcription regulation.
DPY30 has been linked to certain cancers particularly acute myeloid leukemia (AML). Research indicates that abnormal activity of the SET1/MLL complexes possibly involving DPY30 may contribute to the leukemogenic process. Additionally it has connections to developmental disorders where mutations impacting histone modification processes disrupt normal developmental signaling pathways. The connection to proteins like MEN1 which interacts with histone modification complexes highlights its role in disease progression.