Abcam, ab126379, Anti-LYRM5 antibody

Size: 100µL
Rabbit Polyclonal LYRM5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETFRF1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ETFRF1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6IPR1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LYRM5 protein also known as LYR motif containing 5 is a small protein with a mass of approximately 7 kDa. Researchers have identified its expression predominantly in mitochondrial regions where it plays a critical role in mitochondrial function. This protein forms part of the LYR family which is involved in various cellular activities. LYRM5's location in mitochondria suggests its direct involvement in mitochondrial processes and homeostasis.
Biological function summary
LYRM5 functions as an important component in mitochondrial bioenergetics. It associates with the complex known as NADH:ubiquinone oxidoreductase (Complex I) of the mitochondrial respiratory chain. Through this association LYRM5 supports the assembly and stabilization of Complex I a critical step in ATP production. This function highlights its importance in cellular energy metabolism emphasizing LYRM5’s role in maintaining proper mitochondrial function.
Pathways
LYRM5 is actively engaged in the oxidative phosphorylation pathway which is important for ATP generation in cells. It facilitates interactions within Complex I ensuring the efficient transfer of electrons in the electron transport chain. Additionally LYRM5 interacts with proteins such as NDUFS6 (part of Complex I) further illustrating its role in this vital energy-producing pathway.
Alterations or malfunctions of LYRM5 have been implicated in mitochondrial diseases often characterized by defects in energy production. Specifically studies link mutations in LYRM5 to disorders like Leigh syndrome a severe neurological condition. The protein's interaction with Complex I proteins like NDUFS6 also associates it with these mitochondrial pathologies suggesting a critical disease-related role for LYRM5 in maintaining mitochondrial integrity.