Abcam, ab126482, Anti-ZCWPW2 antibody

Size: 100µL
Rabbit Polyclonal ZCWPW2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZCWPW2 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZCWPW2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q504Y3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZCWPW2 also known as Zinc Finger CW-Type PWWP Domain Protein 2 is a protein involved in epigenetic regulation. It has a molecular mass of around 153 kDa. ZCWPW2 plays a role in recognizing and binding to specific histone modifications which contributes to chromatin remodeling and gene expression regulation. Its expression occurs in various tissues including testis which suggests a role in reproductive processes and possibly in spermatogenesis.
Biological function summary
ZCWPW2 functions in modulating chromatin structure by interacting with modified histones. This protein is not known to be part of a large protein complex but it has connections with pathways that regulate gene transcription. By binding to trimethylated histone H3 lysine 36 (H3K36me3) ZCWPW2 facilitates the recruitment of other proteins necessary for transcriptional processes which has implications in cellular differentiation and development.
Pathways
ZCWPW2 participates in the gene expression and chromatin remodeling pathways. It interacts within the histone modification pathway where it associates with proteins like MLL3 and MLL4 which are important for methylation marks establishment. Such interactions indicate ZCWPW2’s involvement in transcriptional regulation by influencing chromatin accessibility ultimately affecting gene activity and tissue-specific gene expression patterns.
Abnormal function or expression of ZCWPW2 relates to cancer and neurodevelopmental disorders. Disruption in its activity can lead to improper gene expression patterns potentially resulting in carcinogenesis. Additionally the connection of epigenetic regulators like ZCWPW2 with cognitive dysfunction highlights its role in neurodevelopmental conditions. Through its chromatin-modifying activities ZCWPW2 may impact pathways involving SETD2 another histone methyltransferase which is also linked to tumorigenesis and cognitive disorders.