Abcam, ab126486, Anti-ZNF717 antibody

Size: 100µL
Rabbit Polyclonal ZNF717 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF717 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF717 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9BY31

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF717 also known as zinc finger protein 717 is a transcription factor characterized by the presence of C2H2-type zinc finger motifs which facilitate DNA binding. This protein weighs approximately 85 kDa and is encoded by the ZNF717 gene. ZNF717 is mainly expressed in the nucleus of human cells where it interacts with specific DNA sequences to regulate gene transcription. Due to its multiple zinc finger domains ZNF717 has the potential to modulate the expression of a wide array of target genes.
Biological function summary
Zinc finger proteins like ZNF717 play roles in the regulation of various cellular processes. ZNF717 acts as a transcriptional regulator influencing the expression of genes involved in cell proliferation and differentiation. As a zinc finger protein ZNF717 often operates as part of larger protein complexes participating alongside other transcription factors to fine-tune cellular functions. These activities indicate that ZNF717 may have an impact on critical biological mechanisms.
Pathways
ZNF717 participates in gene regulation and development pathways. It not only adjusts expressions of genes directly linked to cellular growth but also interacts with proteins like SP1 and REST which are notable transcription factors in regulatory networks. The involvement of ZNF717 in these pathways suggests it could influence processes such as embryonic development and cell cycle control although the exact details of these interactions require further studies to clarify.
ZNF717 has been linked to certain cancers and neurological conditions. Overexpression or malfunction of ZNF717 may contribute to tumorigenesis as its role in gene regulation can disrupt normal cell growth. Researchers have also observed connections between ZNF717 and neurodevelopmental disorders with dysregulation potentially leading to abnormal brain development. ZNF717 interacts with disease-related proteins such as PAX5 in cancer and MECP2 in neurological disorders indicating its potential as a target for therapeutic interventions.