Abcam, ab126606, Anti-Sumo 2 + Sumo 3 + Sumo 4 antibody [EPR7163]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Sumo 2 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7163,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SUMO (Small Ubiquitin-like Modifier) proteins specifically SUMO-2 SUMO-3 and SUMO-4 are small proteins involved in modifying other proteins post-translationally. SUMO-2 and SUMO-3 are nearly identical while SUMO-4 shows some distinct differences. These proteins with an average mass of around 11 kDa covalently attach to lysine residues on target proteins a process known as SUMOylation. Expression of these proteins is widespread throughout eukaryotic cells with high expression levels in the brain heart and liver. SUMO-2 and SUMO-3 often function interchangeably forming poly-SUMO chains unlike SUMO-1.
Biological function summary
Through the attachment to target proteins these SUMO proteins influence various cellular processes like nuclear-cytosolic transport transcriptional regulation and DNA repair. SUMO-2 and SUMO-3 often act as part of a complex with other SUMO proteins enhancing their functional diversity. SUMOylation can alter protein-protein interactions and stabilize protein structure impacting gene expression and cellular response to stress. SUMO-4 due to a unique proline residue shows distinct regulatory functions particularly in stress responses and immune reactions.
Pathways
Protein SUMOylation plays an important role in major signaling pathways such as the NF-kB and p53 pathways. SUMO-2 and SUMO-3 modification can regulate the activity of p53 an important transcription factor in cell cycle control and apoptosis. Their association with the NF-kB pathway influences inflammatory responses. Importantly these modifications can affect proteins like IκBα and MDM2 which are directly involved in regulating NF-kB and p53 activities showing their involvement in maintaining cellular homeostasis and stress responses.
Dysregulation of SUMOylation involving SUMO-2 SUMO-3 and potentially SUMO-4 is linked to cancer and neurodegenerative diseases. In cancer altered SUMO conjugation can influence cell proliferation and apoptosis affecting tumor suppressors like p53. In neurodegenerative disorders such as Alzheimer's disease impaired SUMOylation processes might contribute to the abnormal aggregation of proteins like tau. These associations highlight the significance of SUMO proteins in maintaining cellular health and their potential as therapeutic targets in these diseases.