Abcam, ab126679, Recombinant Human CHMP1B protein

Size: 20µg
Recombinant Human CHMP1B protein is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>85% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q7LBR1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CHMP1B also known as Chromatin Modifying Protein 1B is a component of the ESCRT-III (Endosomal Sorting Complex Required for Transport-III) machinery. This protein has a molecular mass of approximately 23 kDa. It is expressed in various tissues particularly showing a strong presence in brain and kidney tissues. Mechanically CHMP1B plays a role in membrane fission and repair processes contributing to cellular activities such as cytokinesis and endosomal sorting.
Biological function summary
CHMP1B plays a significant role in the proper functioning of cellular processes involving vesicle trafficking and organelle biogenesis. It forms part of the ESCRT-III complex which facilitates the scission of membrane bud necks. This activity is vital for the final stages of cytokinesis as well as in the formation of multivesicular bodies. These functions contribute to maintaining cellular structure and homeostasis.
Pathways
CHMP1B is involved in the ESCRT pathway which is integral to endosomal sorting and membrane remodeling processes. This pathway associates closely with proteins like VPS4 which regulates the disassembly and recycling of ESCRT-III complexes. Additionally CHMP1B participates in the pathway of cytokinesis where it collaborates with proteins such as ALIX to ensure the successful separation of dividing cells.
Disturbances in CHMP1B functionality have associations with neurodegenerative diseases and cancer. Abnormal expression of CHMP1B is frequently observed in neurodegenerative conditions connecting it with other proteins like CHMP2B known for involvement in similar disorders. Furthermore alterations in the expression or function of CHMP1B can contribute to oncogenic processes highlighting its relationship with proteins like Brox that participate in related tumorigenic pathways.