Abcam, ab126735, Anti-eIF5A2 + eIF5A antibody [EPR7411-6]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal eIF5A2 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7411-6,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This product was previously published with the name Anti-eIF5A2 antibody [EPR7411-6]. Following in-house testing that showed reactivity to both recombinant Human eIF5A protein (
ab87457
) and recombinant Human eIF5A2 protein (
ab99140
), the name was updated in January 2021 to Anti-eIF5A2 + eIF5A antibody [EPR7411-6].
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The eIF5A2 protein known also as eukaryotic translation initiation factor 5A2 mechanically functions as a translation elongation factor. It plays a significant role in protein synthesis by aiding in the elongation phase of translation. The eIF5A2 protein has a molecular weight of approximately 17 kDa. Expression of eIF5A2 occurs widely in various tissues with a notable presence in cancerous tissues indicating its potential role in tumorigenesis.
Biological function summary
The protein eIF5A2 is involved in diverse cellular processes beyond translation. It localizes in both the cytoplasm and nucleus affecting cell proliferation differentiation and apoptosis. eIF5A2 is not traditionally considered as part of a complex but interacts with ribosomes during the translation process to exert its function. It also influences the synthesis of specific proteins that are important for maintaining cell cycle machinery and responses to stress.
Pathways
EIF5A2 integrates into the regulation of translation and apoptosis pathways. One key pathway involves its links to the mTOR signaling pathway which affects cell growth and survival. Similar proteins involved in this network include eIF5A another isoform closely related to eIF5A2 and components of the ribosomal machinery. eIF5A2 through its effects on protein synthesis influences pathways that coordinate cellular responses to nutrient availability and growth signals.
Cognitive disorders and various cancers involve the eIF5A2 protein. Aberrant expression and mutation of eIF5A2 can lead to unregulated protein synthesis contributing to cancer progression. The protein has connections with oncogenic pathways where alterations in its expression result in dysregulated cellular growth and survival. eIF5A2 interactions with proteins like c-Myc which is implicated in oncogenesis further establish its role in tumorigenic processes making it a target for cancer research and potential therapeutic intervention.