Abcam, ab126759, Anti-UBE4B antibody [EPR7471]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal UBE4B antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7471,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The UBE4B protein also known as U-box protein 2 (UFD2) is a human protein that plays an important role in the ubiquitination process. This protein with a molecular weight of approximately 139 kDa functions as an E4 ubiquitin ligase. UBE4B facilitates polyubiquitin chain assembly on substrates that have already been ubiquitinated by E3 ligases. It is expressed ubiquitously in human tissues though its expression levels can vary across different cell types.
Biological function summary
UBE4B is important in the regulation of protein homeostasis and cellular stress responses. It acts as a part of a complex with other ubiquitin-proteasome system components enhancing their capacity to mark proteins for degradation. This regulation is important for maintaining cellular health as it aids in disposing of misfolded or damaged proteins. UBE4B has also been implicated in DNA repair processes showcasing its diverse biological functions.
Pathways
UBE4B is involved in the ubiquitin-proteasome pathway an essential mechanism for protein turnover in the cell. This protein plays a role in the degradation of key regulatory proteins which influences cell cycle control and signal transduction pathways such as the p53 pathway. UBE4B interacts with proteins like MDM2 which is involved in the regulation of tumor suppressor p53 thereby connecting UBE4B's functionality to broader cellular processes.
UBE4B has associations with cancer and neurodegenerative diseases. Its role in the p53 pathway ties it closely to various forms of cancer as disruptions in p53 regulation can lead to tumor progression. In neurodegenerative diseases UBE4B's involvement in protein degradation implicates it in conditions like Parkinson's disease where protein misfolding and aggregation are pathological hallmarks. The protein's relationship with others like Parkin further emphasizes its relevance in the context of these disorders.