Abcam, ab126938, Anti-FAM84A antibody

Size: 50µL
Rabbit Polyclonal FAM84A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRATD1 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LRATD1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q96KN4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM84A also known as Family with Sequence Similarity 84 Member A is a protein that plays a role in specific mechanical functions within cells. It has a molecular mass of approximately 24 kDa. This protein is expressed in several tissues with higher expression levels seen in certain carcinoma cell lines. It is frequently found in epithelial tissues indicating its potential involvement in various cellular processes related to these locations.
Biological function summary
Research indicates that FAM84A influences cellular proliferation and migration contributing to normal cell growth and possibly carcinogenic processes. This protein does not associate with any well-defined complex but seems to perform its functions independently or in collaboration with other binding partners yet to be identified. Its role suggests that FAM84A may be important in maintaining cellular architecture and promoting cellular movement especially within epithelial environments.
Pathways
Current studies suggest that FAM84A interacts with cellular pathways associated with cell cycle progression and cancer metastasis. These pathways regulate cell division and expansion contributing to the spread of cancerous cells. FAM84A also shows potential associations with signaling molecules that manage cell motility such as cadherins although direct links in these pathways need more exploration.
FAM84A has been linked to cancer particularly colorectal cancer and prostate cancer. Its upregulation correlates with tumor aggressiveness highlighting its potential as a biomarker for these malignancies. FAM84A also shows interactions with proteins such as p53 which is central to the regulation of cell cycle and apoptosis further supporting its relevance in cancer pathophysiology. Understanding these associations helps in exploring therapeutic approaches targeting FAM84A in certain cancers.