Abcam, ab127094, Recombinant Human STK31 protein

Size: 20µg / 50µg
Recombinant Human STK31 protein is a Human Fragment protein, in the 496 to 1019 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, WB.
Key facts
Purity:>80% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9BXU1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK31 also known as Serine/Threonine Kinase 31 or TDRD8 is a protein kinase involved in phosphorylation processes. This protein has a molecular weight of approximately 67 kDa. It is mostly expressed in testicular tissue where it contributes to germ cell development. The expression of STK31 might vary depending on the developmental stage and cellular environment suggesting a role in reproductive biology.
Biological function summary
The activity of STK31 impacts cellular processes critical for germ cell maturation and division. STK31 interacts within complex networks of proteins and possibly forms part of a larger protein complex involved in orchestrating cell cycle progression. Its enzymatic role aids in regulating checkpoints during cell division ensuring proper cellular replication and integrity within reproductive tissues.
Pathways
The role of STK31 is significant in the regulation of the cell cycle and PI3K/AKT signaling pathways. This kinase participates in signaling cascades that control cell proliferation and survival aligning with its primary function in germ cells. STK31's activity relates to other proteins in these pathways such as CDK and AKT which mediate various aspects of cellular growth and replication helping maintain balance and function in cellular contexts.
STK31 has connections to germ cell tumors and testicular cancer. Aberrant expression or mutations of STK31 are associated with testicular germ cell tumors indicating its critical role in normal and pathological conditions. It shares a link with proteins like OCT4 and NANOG which are known for roles in stem cell pluripotency and are found deregulated in certain cancers implicating STK31 in oncogenic processes within reproductive tissues.