Abcam, ab127690, Anti-p63RhoGEF antibody

Size: 50µL
Rabbit Polyclonal p63RhoGEF antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGEF25 aa 200-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGEF25 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.Q86VW2

Product details:
Keep as concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P63RhoGEF also known as RhoGEF GEF is a guanine nucleotide exchange factor that activates RhoA. This protein possesses a molecular mass of approximately 65 kDa. p63RhoGEF shows prominent expression in various tissues including the thymus lungs and brain. It activates RhoA by facilitating the exchange of GDP for GTP essential in RhoA signaling. As a member of the Dbl family of GEFs p63RhoGEF participates specifically with the GTPase activity of RhoA leading to various downstream effects.
Biological function summary
P63RhoGEF serves important roles in signaling pathways that regulate cytoskeletal dynamics and cell morphology. It does not typically form part of a complex but interacts directly with several proteins in cellular signaling. Through activation of RhoA p63RhoGEF influences processes such as cell migration division and adhesion. It plays a role in the reorganization of the actin cytoskeleton important for maintaining cellular shape and facilitating motile functions.
Pathways
P63RhoGEF functions within the RhoA signaling and GPCR pathways. It interacts with G-protein coupled receptors (GPCRs) to mediate signals that lead to the activation of RhoA. p63RhoGEF has connections to proteins like Gαq which directly influence its activity within these pathways. This interplay enables p63RhoGEF to translate extracellular signals into intracellular responses that affect cell structure and movement.
P63RhoGEF exhibits significant associations with cancer and cardiovascular diseases. Through its regulation of RhoA alterations in its activity can contribute to tumorigenesis and metastasis. Overactive RhoA signaling facilitated by p63RhoGEF can lead to increased cell migration and invasiveness frequently observed in cancer progression. Furthermore in the context of cardiovascular disease p63RhoGEF interacts with endothelial proteins influencing vascular tone and blood pressure implicating it in conditions like hypertension.