Abcam, ab127743, Anti-ZNF418 antibody

Size: 50µL
Rabbit Polyclonal ZNF418 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF418 aa 150-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF418 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.Q8TF45

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF418 also known as Zinc Finger Protein 418 is a member of the Kruppel-like factor family which plays a role in transcriptional regulation. This protein has a mass of approximately 84 kDa and contains characteristic zinc finger domains that enable it to bind to DNA. ZNF418 is primarily expressed in the testis with lower levels observed in other tissues like the brain and liver. It interacts with specific DNA sequences to regulate gene expression influencing cellular functions by acting as a transcription factor.
Biological function summary
ZNF418 functions in the regulation of genes that control cell differentiation and growth. It does not work alone but is part of protein complexes that expand its regulatory capacity. ZNF418 collaborates with other zinc finger proteins to modulate the transcription of target genes contributing to cellular processes like proliferation and apoptosis. This regulation ensures proper cell cycle progression and balance essential for maintaining healthy cellular environments.
Pathways
ZNF418 is involved in pathways related to signal transduction and transcriptional regulation. It participates in the Wnt signaling pathway which is critical for development and cell fate decisions. Within this pathway ZNF418 interacts with proteins such as β-catenin influencing gene expression patterns. Additionally it has connections to the Notch signaling pathway where its role affects decisions in stem cell differentiation and maintaining tissue homeostasis.
Dysregulation of ZNF418 is linked to cancers and reproductive disorders. Abnormal expression levels can contribute to oncogenesis due to disrupted control of cell proliferation and apoptosis pathways. In cancer contexts ZNF418 associates with proteins like p53 influencing the tumor suppressor’s capacity to mediate DNA repair and cell cycle control. Moreover disruptions involving ZNF418 in reproductive tissues may lead to disorders such as infertility where interactions with proteins like FSH affect hormonal regulation.