Abcam, ab127942, Anti-NADase antibody

Size: 100µL
Rabbit Polyclonal NADase antibody. Suitable for WB, IP, FuncS (Neut/Block), Neut and reacts with Streptococcus sp. 'group A', Streptococcus sp. 'group C' samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Streptococcus sp. 'group C', Streptococcus sp. 'group A',
Applications:Neut, FuncS (Neut/Block), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab127942 reacts with NADase of Group A, C,and G origins

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-pH: 6 - 8.5Preservative: 0.09% Sodium azideConstituents: 99% Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NADase also known as Nicotinamide Adenine Dinucleotide glycohydrolase is an enzyme with a major role in catalyzing the hydrolysis of NAD+ into nicotinamide and ADP-ribose. This enzyme has an approximate mass of about 30-40 kDa although exact mass can vary depending on the isoform and organism. You can commonly find NADase expressed in various tissues including immune cells and neuronal tissues reflecting its broad functional significance.
Biological function summary
The enzyme facilitates cellular signaling and metabolic regulation by modulating the availability of NAD+ a critical substrate and cofactor in numerous metabolic pathways. NADase often functions as part of a larger protein complex participating in the regulation of calcium signaling and apoptosis. It also plays an important role in maintaining cellular homeostasis influencing processes like energy metabolism and DNA repair.
Pathways
NADase contributes significantly to NAD+ metabolism and calcium signaling pathways. It interacts with other enzymes such as Sirtuins which use NAD+ for deacetylation reactions involved in gene expression regulation and aging. In these pathways NADase influences the cellular response to metabolic stress and helps maintain the balance between energy production and consumption.
NADase has links to neurodegenerative diseases and certain types of cancer. Alterations in NADase activity can affect the progression of Alzheimer’s disease where disturbed NAD+ metabolism plays a role in neuronal dysfunction. In some cancers the enzyme's dysregulation can alter cellular metabolism enhancing tumor survival. NADase connects to these diseases through interactions with proteins like PARP-1 which are involved in DNA damage repair and apoptosis regulation.