Abcam, ab128006, Anti-TMEPAI antibody

Size: 50µg
Rabbit Polyclonal TMEPAI antibody. Suitable for IHC-P, ELISA, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PMEPA1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PMEPA1. The exact immunogen used to generate this antibody is proprietary information.Q969W9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEPAI also known as TMPRSS6-associated product containing transcript is a transmembrane protein. It has a molecular weight of approximately 26 kDa. TMEPAI is widely expressed in various tissues with particularly high expression in the lungs prostate and breast. It interacts with the cytoplasmic signaling proteins through its PY motifs modulating their activities directly. TMEPAI plays an important role in cellular pathways affecting cellular functions and interactions.
Biological function summary
This protein modulates signaling pathways and cell growth regulation. It is well known for its involvement in the TGF-beta (Transforming Growth Factor-beta) signaling pathway. TMEPAI acts as a negative regulator inhibiting TGF-beta's tumor-suppressive functions through interaction with Smad proteins. While it does not form part of a complex itself it significantly influences the functional dynamics of the TGF-beta pathway constituents impacting cellular proliferation and survival.
Pathways
TMEPAI exerts its functional significance primarily within the TGF-beta and PI3K/Akt signaling pathways. In the TGF-beta pathway TMEPAI modulates the signaling cascade by interacting with Smad2/3 and Smad4. The regulation of these proteins by TMEPAI suppresses TGF-beta-induced growth inhibition. In the PI3K/Akt pathway TMEPAI influences cell survival and proliferation indirectly through these interactions positioning it as an important modulator in these pathways.
TMEPAI has significant implications in cancer particularly in breast and prostate cancer. It facilitates cancer progression by overriding the tumor-suppressive effects of TGF-beta signaling. The interactions with Smad proteins like Smad2/3 highlight its role in oncogenic pathways. Moreover in prostate cancer the dysregulation of TMEPAI links with increased aggressive behavior of cancer cells exacerbating disease progression. Understanding these interactions provides insights into potential targets for therapeutic intervention in these diseases.