Abcam, ab128224, Anti-Eph antibody

Size: 100µg
Rabbit Polyclonal Eph antibody. Suitable for ELISA, WB and reacts with Drosophila melanogaster samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Drosophila melanogaster,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Eph receptors also known as EPH receptors or EPHA/EPHB are a group of receptor tyrosine kinases. Typically they are involved in cellular processes like cell adhesion shape and movement. Eph receptors play a role in the signaling dynamics between cells and tissues particularly through interactions with ephrin ligands. These receptors exhibit weights of around 100-125 kDa and are found in various tissues including the brain where they contribute to nervous system development and function.
Biological function summary
Eph receptors influence cell positioning and boundary formation in the development of tissues and organs. They are a part of receptor-ligand complexes and engage in bidirectional signaling that impacts cellular dynamics. The Eph/ephrin interactions affect neural development angiogenesis and tissue patterning where they help define the spatial organization of cells and guide cell migration.
Pathways
These receptors integrate into the Eph/ephrin signaling and axon guidance pathways. Within these pathways they interact with several molecules including Rac1 and RhoA which are important for cytoskeleton reorganization. Eph receptors also link to MAP kinase pathways influencing cellular proliferation differentiation and migration decisions. This establishes their role in determining cell fate and positioning during embryogenesis and wound healing.
Eph receptors have associations with cancer and neurological disorders. Dysregulation of Eph-ephrin signaling can contribute to tumorigenesis affecting tumor growth metastasis and angiogenesis. They also relate to Alzheimer's disease where aberrant Eph receptor signaling may disrupt cellular communication and synapse function. Interactions with proteins like ADAM10 and NMDA receptors further connect these pathways to disease pathogenesis making Eph receptors potential targets for therapeutic intervention.