Abcam, ab128708, Anti-RSV glycoprotein antibody [8C5 (9B6)]

Size: 200µg
Mouse Monoclonal SHMT1 antibody. Suitable for ELISA, WB and reacts with Respiratory syncytial virus samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:8C5 (9B6),
Isotype:IgG2b,
Carrier free:No,
Reacts with:Respiratory syncytial virus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab128708 is specific for the major glycoprotein G of Respiratory Syncytial virus (RSV).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RSV glycoprotein also known as the fusion protein or F protein plays a significant role in the life cycle of the respiratory syncytial virus (RSV). This protein is responsible for mediating the fusion of the viral envelope with the host cell membrane enabling viral entry. The RSV glycoprotein possesses a mass of approximately 70-90 kDa. It expresses on the surface of the RSV particle and is essential for the initial infection process in respiratory epithelial cells.
Biological function summary
The RSV glycoprotein facilitates membrane fusion and viral genome entry into host cells acting as a trigger for the viral replication process. The F protein undergoes a conformational change that drives fusion making it essential for the RSV pathogenesis. It does not typically exist as part of a larger complex. This protein achieves membrane fusion activity by interacting with a host cell receptor although the exact receptor remains under investigation.
Pathways
The RSV glycoprotein interacts with the host cell membrane fusion pathway a critical step in viral infection. It shares functional similarities with the fusion proteins of other paramyxoviruses such as the measles virus F protein. The RSV glycoprotein's activity in the fusion pathway highlights its role in viral entry and propagation. These pathways emphasize the significant overlap in viral entry strategies used by related respiratory viruses.
The RSV glycoprotein directly relates to respiratory infections particularly bronchiolitis and pneumonia in infants and the elderly. RSV is a leading cause of severe respiratory illness in these populations and the glycoprotein's role in viral entry makes it a target for vaccine and antiviral drug development. The RSV glycoprotein has associations with the nucleoprotein of RSV as both play roles in the virus's replication cycle and pathogenicity. Understanding these interactions improves insights into the development of effective therapeutic interventions.