Abcam, ab128720, Anti-CEACAM1 + CEACAM6 + CEACAM3 antibody [YTH71.3]

Size: 100µg
Rat Monoclonal CEAM1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CEACAM3 protein.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:YTH71.3,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing CEACAM3 protein. The exact immunogen used to generate this antibody is proprietary information.P40198,
Specificity:ab128720 recognises Human CEACAM1 + CEACAM6 + CEACAM3. Clone YTH71.3 reacts with transfectants containing BGPa, NCA and CGM1a which are CEA subfamily members.

Product details:
Should this product contain a precipitate we recommend microcentrifugation before use. Storage in frost-free freezers is not recommended.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM1 CEACAM6 and CEACAM3 are members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family. They function as cell surface glycoproteins. CEACAM1 also known as CD66a or BGP1 has a mass of approximately 120 kDa. It is expressed in numerous tissues including liver lung and immune cells. CEACAM6 or CD66c weighs about 37 kDa and is found in epithelial cells and certain cancer types. CEACAM3 or CD66d weighs around 32 kDa and appears mainly in granulocytes. These proteins assist in cell signaling and play roles in cell adhesion and immune responses.
Biological function summary
Each of these proteins participates in various processes within the body. CEACAM1 serves as a mediator for intercellular adhesion and is involved in immune modulation. It can dimerize and sometimes form larger complexes with other CEACAM family members. CEACAM6 though similar exhibits a more restrictive role within cancer cell adhesion and signaling. CEACAM3 acts primarily in pathogen recognition within granulocytes operating independently rather than forming complexes. The CEACAM family's ability to interact with immune cells often impacts cellular responses to environmental changes and infectious agents.
Pathways
These proteins influence several significant pathways within the body. CEACAM1 and CEACAM6 engage in pathways related to immune response regulation and signaling. Specifically they play roles in the Src family kinase and MAPK signaling pathways which guide cellular proliferation and survival. Related proteins such as CEACAM4 and CEACAM5 show interactions in similar pathways highlighting their collective part in immune system modulation. CEACAM3 on the other hand links to pathways involved in phagocytosis and pathogen clearance cooperating with innate defense mechanisms.
These proteins link to conditions such as cancer and infections. CEACAM1 expression often alters in various cancers impacting tumor progression and immune evasion. It becomes associated with proteins like EGFR in tumorigenic pathways. CEACAM6 links closely to conditions like colorectal cancer where it assists in cell migration and invasion and interacts with integrins and other adhesion molecules. CEACAM3's role in recognizing and binding bacteria connects it to infectious diseases providing an essential defense mechanism in the immune response often involving proteins like TLRs to enhance pathogen detection.