Abcam, ab128726, Anti-Rabies Virus antibody [Rab-50]

Size: 500µg
Mouse Monoclonal Rabies Virus antibody. Suitable for ELISA, WB, ICC/IF and reacts with Rabies virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Rabies Virus protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:Rab-50,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Rabies virus,
Applications:ELISA, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab128726 shows conformation dependent specificity for the viral envelope glycoprotein. Not known to react with any other organism.

Product details:
Should this product contain a precipitate we recommend microcentrifugation before use. Storage in frost-free freezers is not recommended. Spleen cells from immunised Balb/c female mice were fused with cells of the NSO myeloma cell line

Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Rabies Virus also known scientifically as Lyssavirus is a neurotropic virus with a negative-sense single-stranded RNA genome. Its genome has a mass of approximately 12000 nucleotides. The virus mainly expresses itself in the central nervous system of mammals including humans. The structure comprises a helical ribonucleoprotein core surrounded by a viral envelope. This form of viral organization facilitates its movement through neuronal tissues and across synapses.
Biological function summary
The Rabies Virus is responsible for the transmission of rabies a fatal encephalitis. The virus operates by invading the nervous system effectively avoiding the host's immune response through rapid neural transmission. It forms complexes with host cellular machinery to hijack cellular processes for its replication and dissemination. The virus reaches high concentrations in the brain and salivary glands leading to its transmission through animal bites.
Pathways
Several neural entry and propagation routes are implicated in Rabies Virus infection. The molecular pathways involve interactions with neuronal cell membrane receptors and require other proteins such as nicotinic acetylcholine receptor for effective binding. The viral proteins including glycoprotein play critical roles in facilitating these interactions which modulate the transmission pathways across the nervous system.
Rabies Virus is directly related to the disease rabies a neurodegenerative condition resulting in fatal encephalitis if untreated. Understanding its pathway helps in developing vaccines and therapeutic strategies like anti-rabies immunoglobulins. The virus's interaction with proteins such as the nicotinic acetylcholine receptor highlights potential therapeutic targets to limit neural invasion and control the disorder's progression.