Abcam, ab128944, Anti-Inhibin beta B antibody [EPR2788(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Inhibin beta B antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2788(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Inhibin beta B also known as INHBB protein is a subunit of the inhibin protein family. This protein has a molecular mass near 45 kDa. Inhibin beta B is expressed in the pituitary gland reproductive organs such as the ovary and testis and also can be found in the placenta. The subunit can dimerize with other members of the inhibin family to form dimers like activin AB which play a role in diverse physiological processes.
Biological function summary
The inhibin protein and its subunits such as inhibin beta B participate in the regulation of reproductive functions. It is part of the activin-inhibin complex influencing the secretion of follicle-stimulating hormone (FSH). Inhibin beta B can bind with another inhibin beta chain or with inhibin alpha to form different dimers which exert distinct biological effects through their interaction with specific receptors on target cells.
Pathways
Inhibin beta B is an essential component in the TGF-beta signaling pathway. It contributes to the regulation of cell growth and differentiation. Inhibin beta B interacts closely with proteins like follistatin which binds to activins and modulates their activities. The participation of inhibin beta B in this signaling pathway holds significant implications for its function in both reproductive and systemic processes.
Inhibin beta B shows a connection to conditions like polycystic ovary syndrome (PCOS) and certain reproductive tumors. The imbalanced expression of this protein can contribute to the pathophysiology of these disorders. Alongside proteins such as inhibin alpha inhibin beta B's altered signaling activity in the TGF-beta pathway may influence disease progression making it a target of interest for therapeutic interventions.