Abcam, ab129075, Anti-MFF antibody [EPR7360]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MFF antibody. Suitable for WB and reacts with Human samples. Cited in 23 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7360,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The mitochondria fission factor (MFF) also known as C2orf33 or mitochondrial fission factor plays a significant role in the control of mitochondrial fission. MFF has a molecular weight of approximately 29 kDa and is expressed abundantly in tissues with high energy demands including the heart brain and muscles. By directly interacting with the dynamin-related protein 1 (Drp1) MFF facilitates the Drp1 recruitment to the mitochondrial outer membrane which is a critical step in the mitochondrial division process.
Biological function summary
The MFF protein promotes the division of mitochondria which is vital for maintaining the health and function of cells. MFF is a part of the mitochondrial fission complex a group of proteins responsible for regulating mitochondrial morphology. It plays an important role in cellular processes such as energy production apoptosis and cellular response to stress by modulating mitochondrial dynamics.
Pathways
MFF interacts with other proteins to regulate mitochondrial fission which is an integral part of the mitochondrial dynamics pathways. It participates prominently in pathways controlling energy metabolism and apoptosis. MFF works closely with proteins like Drp1 and has connections to pathways involving fission and fusion processes that maintain mitochondrial homeostasis and adapt to metabolic needs.
Disruptions in MFF function are associated with conditions like neurodegenerative diseases and metabolic disorders. Impaired mitochondrial fission can contribute to diseases such as Alzheimer's where abnormal mitochondrial dynamics play a role in disease progression. MFF's connection with Drp1 also implicates it in metabolic disorders where energy production and mitochondrial function are disrupted indicating its involvement in maintaining cellular energy balance and neuronal health.