Abcam, ab129116, Anti-PFDN5 antibody [EPR7755]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PFDN5 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7755,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Prefoldin Subunit 5 (PFDN5) also known as PFD5 or MKBP is a protein that forms part of the prefoldin complex. This protein which has a mass of around 15.7 kDa plays an important mechanical role in delivering nascent polypeptide chains to the chaperonin complex for proper folding. PFDN5 is expressed widely across various tissues with notable expression in the brain and testis. Its involvement in such fundamental processes suggests it supports maintaining cellular stability and homeostasis.
Biological function summary
PFDN5 contributes to the assembly and stabilization of cytoskeletal structures by participating in tubulin folding processes. It functions as a component of the prefoldin complex a hexameric molecular chaperone. Through its action PFDN5 assists in the folding and assembly of cytoskeletal proteins such as actin and tubulin ensuring proper cellular architecture and transport functions. The protein’s interaction within the complex highlights its support in cellular dynamics and structural maintenance.
Pathways
PFDN5 integrates into important cellular pathways related to protein folding and cytoskeletal assembly. It participates prominently in the tubulin folding pathway which is essential for microtubule formation. In this context PFDN5 interacts significantly with chaperonin-containing T-complex protein 1 (CCT) to facilitate the assembly of tubulin monomers into functional microtubules. These interactions highlight PFDN5’s role in maintaining cellular integrity and facilitating intracellular transport mechanisms.
PFDN5 presents associations with certain cancers particularly glioma. Altered expression or function of PFDN5 can disrupt normal cytoskeletal processes contributing to the irregular cell proliferation observed in gliomas. It has shown interactions with proteins like CCT2 in such pathological conditions. Furthermore PFDN5’s involvement in neurodegenerative processes links it to diseases like amyotrophic lateral sclerosis (ALS). In these contexts PFDN5 might influence disease progression through its impact on protein stability and cellular architecture.