Abcam, ab129162, Anti-NARS antibody [EPR8221]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NARS antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8221,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NARS also known as asparaginyl-tRNA synthetase is an enzyme with a mass of about 65 kDa. This enzyme plays an important role in protein synthesis by catalyzing the attachment of asparagine to its corresponding tRNA. NARS is expressed in various tissues across the body with noticeable levels in the liver and brain. The enzyme operates as a homodimer and requires ATP for its catalytic activity which facilitates the formation of asparaginyl-tRNA ensuring proper translation of genetic information during protein synthesis.
Biological function summary
As an essential component of the protein synthesis machinery NARS functions to ensure the fidelity and efficiency of genetic translation. It does not form part of a larger complex but its activity is critical in maintaining cellular function by facilitating accurate amino acid incorporation into growing polypeptide chains. This precise activity is necessary for cellular viability and the prevention of erroneous protein synthesis which could lead to dysfunctional proteins and cellular stress.
Pathways
NARS interacts with multiple biological pathways including the aminoacyl-tRNA biosynthesis pathway and the protein translation pathway. NARS’s role in aminoacyl-tRNA biosynthesis is important as it interacts with other aminoacyl-tRNA synthetases to maintain balanced protein synthesis. In the protein translation pathway it works alongside other elongation factors such as EF-Tu which ensures the correct delivery of aminoacyl-tRNA to the ribosome thereby orchestrating the translation process.
NARS's dysfunction links to neurodegenerative disorders and certain cancers. Mutations or aberrant expression of NARS may result in impaired protein synthesis contributing to neurological conditions such as Charcot-Marie-Tooth disease. Other proteins involved in these disorders include GARS another tRNA synthetase associated with similar hereditary neuropathies. Additionally increased expression of NARS has been noted in some cancerous tissues implicating its potential role in tumorigenesis and highlighting its relevance in cancer pathways.