Abcam, ab129164, Anti-LSM2 antibody [EPR7216]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LSM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7216,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LSM2 also known as Like-Smith 2 is a protein involved in RNA processing and stabilization. It has a mass of approximately 14 kDa. This protein is mainly expressed in the cytoplasm and nucleus and its presence is critical in cells with active RNA metabolism. The structure of LSM2 enables it to participate in RNA decay and splicing pathways making it an important player in RNA regulation.
Biological function summary
Proteins coordinate complex molecular processes within cells. LSM2 is part of the Lsm1-7 complex which binds to the 3' ends of mRNA and facilitates mRNA decapping and decay. This complex supports RNA metabolism by modulating mRNA stability and is essential for proper cellular function and response to environmental changes.
Pathways
The functions of LSM2 integrate into RNA processing pathways like mRNA decay and splicing. In the mRNA decay pathway LSM2 through the Lsm1-7 complex works alongside decapping proteins to regulate mRNA turnover influencing gene expression levels. Additionally in splicing LSM2 influences the splicing machinery interacting with proteins like U6 snRNA ensuring accurate splicing of pre-mRNA.
Researchers have linked abnormalities in LSM2 function to neurodegenerative diseases such as spinal muscular atrophy. Mutations or malfunctions in LSM2 disrupt RNA processing especially mRNA decay leading to improper gene expression. These disruptions can involve proteins like SMN (Survival Motor Neuron) highlighting LSM2's role in maintaining neuron integrity and function.