Abcam, ab129815, Anti-ALDH1A3 antibody

Size: 100µg
Anti-ALDH1A3 antibody (ab129815) is a rabbit polyclonal antibody detecting ALDH1A3 in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Over 30 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of ab129815 are tested in WB. Previous batches were additionally validated in ICC/IF, and IHC-P. These applications are still expected to work and are covered by our Abpromise guarantee.

Product details:
What is this antibody validated in?
Anti-ALDH1A3 antibody (ab129815) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of ALDH1A3?
Anti-ALDH1A3 (ab129815) specifically detects a band for ALDH1A3 (UniProt: P47895) at a molecular weight of 56kDa.
Trusted by the scientific community
Anti-ALDH1A3 (ab129815) was first used in a scientific publication in 2012 and has been cited over 30 times in peer-reviewed journals.
Reviewed by scientists
Anti-ALDH1A3 (ab129815) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH1A3 also known as Aldehyde Dehydrogenase 1 Family Member A3 is an enzyme with a molecular mass of approximately 55 kDa. It belongs to the aldehyde dehydrogenase family which is responsible for oxidizing aldehydes into carboxylic acids. ALDH1A3 plays an important role in the metabolism of retinaldehyde into retinoic acid an important biochemical reaction in the body. This enzyme shows high expression in tissues such as the liver kidney and neural tissue.
Biological function summary
The role of ALDH1A3 extends beyond simple metabolic processes. It is involved in the regulation of retinoid signaling influencing various cellular processes such as differentiation and proliferation. ALDH1A3 does not operate in isolation; it is often part of a complex interplay of enzymes that regulate local concentrations of retinoic acid which serves as a signaling molecule influencing gene expression. This regulatory capability underlines its importance in developmental and physiological patterns.
Pathways
ALDH1A3 is essential in the retinoic acid signaling pathway and the metabolic pathway of vitamin A derivatives. It interacts with other ALDH family members such as ALDH1A1 and ALDH1A2 in the synthesis and degradation of retinoic acid. Through these pathways ALDH1A3 also impacts the Wnt and Hedgehog pathways which are important for cellular growth and differentiation.
ALDH1A3 connects with several neurodegenerative and cancer conditions. Studies have indicated a correlation between ALDH1A3 expression and certain types of cancer including breast cancer and glioblastoma. In cancer aberrant ALDH1A3 levels can affect cancer stem cell properties and tumor progression. Additionally the protein interacts with other proteins like ALDH1L1 and ALDH3A1 which might also play roles in tumor metabolism and resistance to chemotherapy.