Abcam, ab130398, Anti-SLC38A9 antibody

Size: 100µL
Rabbit Polyclonal SLC38A9 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC38A9 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC38A9 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8NBW4

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC38A9 also known as SNAT9 functions as an amino acid transporter and sensor within lysosomes. It specifically mediates the transport of essential amino acids and related signals from the lysosomal lumen to the cytoplasm. The protein has a mass of approximately 61 kilodaltons and is primarily expressed in tissues with high metabolic activity like the liver kidneys and brain. This expression pattern supports its role in cellular and metabolic homeostasis.
Biological function summary
This protein serves as a component of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. SLC38A9 directly interacts with the lysosomal surface to connect amino acid availability to mTORC1 activation. By doing so it influences cell growth and autophagy processes in response to amino acid levels. As a part of the mTORC1 complex SLC38A9 plays an important function in translating extracellular cues to intracellular responses.
Pathways
SLC38A9 is integral in the amino acid sensing mechanism that regulates the mTORC1 pathway. This pathway controls vital processes like protein synthesis and cell proliferation. The protein partners with other key players in the mTOR signaling pathway including Rag GTPases and Raptor to relay amino acid abundance to the mTORC1 complex. This relationship ensures that cellular growth processes are synchronized with available nutrition resources.
SLC38A9 is implicated in metabolic diseases and cancer. Dysregulation of amino acid sensing and mTORC1 activity mediated through SLC38A9 contributes to metabolic disorders such as obesity and type 2 diabetes. Moreover its involvement with mTORC1 links it to cancer progression as mTORC1 is often upregulated in tumors. This relationship suggests a potential therapeutic interest in targeting SLC38A9 together with proteins like mTOR for disease intervention.