Abcam, ab130996, Anti-THRAP5 antibody

Size: 100µg
Rabbit Polyclonal THRAP5 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human MED16 aa 550-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MED16 aa 550-600. The exact immunogen used to generate this antibody is proprietary information.Q9Y2X0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab130996 is affinity purified using an epitope specific to THRAP5 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THRAP5 also known as TRIP13 and thyroid hormone receptor-associated protein 5 is a protein with a molecular mass of approximately 36 kDa. This protein usually operates in the nucleus as a part of transcriptional regulation processes. It is strongly expressed in various tissues including the liver kidney and brain indicating its widespread presence in the body. Mechanically THRAP5 interacts with nuclear hormone receptors and acts as a coactivator which means that it helps facilitate the transcription of specific genes.
Biological function summary
THRAP5 functions as part of a larger complex called the Mediator complex which is essential for the regulation of gene expression. This complex serves as a bridge linking transcriptional activators and the RNA polymerase II machinery thereby influencing the transcription of genes downstream. THRAP5 is involved in various regulatory roles that include assisting in the activation of nuclear receptors. Its involvement in the complex structure of Mediator indicates its role in controlling gene expression.
Pathways
THRAP5 involves itself in the regulation of transcriptional processes and may influence the ERK/MAPK signaling pathway. This pathway is important for cell growth proliferation and differentiation. The protein interacts with transcription factors and other proteins like ERK1/2 to modulate these pathways. Its role in facilitating communication between hormone receptors and transcriptional machinery positions it as an important regulatory hub in cellular signaling.
THRAP5 interacts with various proteins involved in cancer and metabolic disorders. Studies have linked its aberrant expression to certain cancers including breast cancer where it might play a role in tumor progression. Additionally metabolic conditions like obesity have shown connections to THRAP5 potentially through interactions with PPARs (peroxisome proliferator-activated receptors) which are important for metabolic regulation. Understanding the contribution of THRAP5 in these diseases could offer insights into novel therapeutic targets.