Abcam, ab130999, Anti-Pur B antibody

Size: 100µg
Rabbit Polyclonal Pur B antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PURB aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PURB aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96QR8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab130999 is affinity purified using an epitope specific to Pur B immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pur B also known as purine-rich element-binding protein B is involved in DNA binding and transcriptional regulation. It is a 40 kDa protein localized in the nucleus and highly expressed in tissues with active cellular proliferation like the brain and the heart. Pur B associates with the purine-rich single-stranded DNA influencing the function and stability of genetic elements within these tissues.
Biological function summary
Pur B plays a significant role in cell growth and differentiation. It forms part of a multi-protein complex essential for regulating the expression of genes vital for cellular processes. The complex influences transcriptional activity altering how certain genes are turned on or off which ultimately impacts cellular function and development.
Pathways
Pur B is integral to the regulation of transcription and nucleic acid processes. It is involved in pathways like the response to stress and regulation of apoptosis. Within these pathways Pur B interacts with other transcription factors such as Pur A contributing to the precise control of gene expression essential for maintaining cellular integrity and responding to physiological changes.
Pur B displays an association with neurodegenerative diseases and cancer. Dysregulation of Pur B levels or function links to Alzheimer’s disease where it affects neural development and function often alongside Pur A. Additionally abnormal Pur B activity is observed in certain cancers potentially due to its role in gene transcription involved in cell proliferation where it might interact with oncogenic factors exacerbating tumor progression.