Abcam, ab131034, Anti-TUB 1 antibody [EPR8241]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TUB antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8241,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUB 1 also known as Tubby-like protein 1 is a monomeric protein with a mass of approximately 54 kDa. This protein has involvement in cellular processes due to its structural properties. TUB 1 expression occurs in various tissues including the brain and retina where it plays roles in critical functions. The precise mechanical role remains under investigation but there is evidence for its interaction with several cellular components.
Biological function summary
Tubby-like protein 1 is essential for maintaining cellular homeostasis. The protein associates with other molecules as part of a multi-protein complex exhibiting regulation of gene expression and involvement in signal transduction. TUB 1 assists in the response to external stimuli especially within neural tissues which suggests its contributions to neurological signaling pathways.
Pathways
Tubby-like protein 1 is significantly involved in signaling pathways related to neurodevelopment and vision such as the PI3K/Akt pathway. This protein works closely with PI3K signaling proteins contributing to cellular growth and survival. Through these pathways TUB 1 helps manage signal transduction processes along with other protein partners involved in neuronal function.
Researchers link Tubby-like protein 1 to obesity and retinitis pigmentosa. Mutations or dysregulations in TUB 1 can impact normal protein interactions affecting pathways associated with these conditions. The protein's interaction within these pathways together with leptin receptor and visual cycle proteins indicates a relationship with metabolic regulation and visual impairment disorders.