Abcam, ab131041, Anti-Leukotriene B4 Receptor/BLT antibody [EPR7113]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Leukotriene B4 Receptor/BLT antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7113,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Leukotriene B4 Receptor often referred to as BLT or BLT1 plays a significant mechanical role in the immune response by binding to leukotriene B4 (LTB4) a potent chemoattractant. This receptor has a molecular mass of about 45 kDa. It expresses primarily on leukocytes including neutrophils macrophages and certain T cells. Furthermore BLT1 can also be observed in other tissues such as the spleen and liver where immune modulation has essential roles.
Biological function summary
The function of BLT1 involves mediating cell migration particularly during inflammatory responses. When LTB4 binds to BLT1 it activates intracellular signaling pathways that lead to chemotaxis and activation of immune cells. This receptor does not function in isolation; it forms part of receptor complexes on the cell surface to facilitate effective signal transduction. Although its name suggests specificity BLT1 can interact with other related lipid mediators amplifying its role in inflammation.
Pathways
Leukotriene B4 receptor BLT1 is integral to the arachidonic acid pathway and the GPCR signaling pathway. In the arachidonic acid pathway BLT1 contributes to the production of inflammatory mediators that recruit immune cells to sites of injury or infection. This receptor shares pathways with other GPCRs facilitating coordinated responses to external stimuli. It is closely related to protein kinase C (PKC) in the pathways which plays a role in signal transduction and cellular communication.
Leukotriene B4 receptor BLT1 has significant implications in chronic inflammatory diseases such as asthma and rheumatoid arthritis. Overactivation of BLT1 can result in excessive recruitment of immune cells exacerbating inflammation and tissue damage in these conditions. The receptor is also connected to COX-2 which is involved in the inflammation process linking BLT1 to the broader picture of inflammatory pathways in disease states. Understanding BLT1's role in these diseases helps identify potential therapeutic targets for managing inflammation-related pathologies.