Abcam, ab131049, Anti-HOXA4 antibody

Size: 100µg
Rabbit Polyclonal HOXA4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA4 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HOXA4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q00056

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXA4 also known as Homeobox A4 is a transcription factor which belongs to the homeobox gene family. It plays a significant role in regulating gene expression during embryonic development. HOXA4 has a molecular mass of approximately 33 kDa. It expresses widely in various tissues with particularly high expression noted in the anterior part of the spinal cord during early development. Being a member of the homeobox cluster on chromosome 7 HOXA4 shares functional similarities with other HOX proteins.
Biological function summary
HOXA4 influences the patterning of body structures during embryonic development. It functions as part of the larger HOX gene network which coordinates timing and localization in the development of the cranial-caudal axis. This gene network is highly conserved across mammals and helps in the formation of specific tissues including thoracic vertebrae. As part of this complex HOXA4 maintains precise regulation of downstream targets essential for morphogenesis.
Pathways
HOXA4 plays an integral role in the developmental signaling pathway specifically the Wnt signaling pathway. This pathway is important for regulating cellular processes like cell fate determination proliferation and migration. Within the pathway HOXA4 interacts with other HOX proteins such as HOXC9 to modulate the expression of genes that guide embryonic segmentation and differentiation. Coordination of these developmental pathways ensures proper formation of anterior skeletal structures in vertebrates.
HOXA4 associations include congenital malformations and certain cancers. Abnormal expression of HOXA4 links to developmental disorders such as vertebral defects where misregulated HOX gene activity leads to skeletal anomalies. Additionally overexpression of HOXA4 has been implicated in the proliferation of tumor cells in certain cancers such as leukemia. In these contexts interactions with other proteins like HOXB4 may influence disease progression and chemoresistance.